Table 2.

Brain Regions (De-)activated During the Modified Cold Pressor Test

Contrast	Brain Region	L/R	BA	MNI			Voxel Size	t-value	p value of Cluster
				x	y	z
Pain>ctl
	Insula	L	13	−34	6	10	6349	8.89	<0.001
	Putamen			−24	4	10		8.09	<0.001
	Caudate nucleus	L		−18	−26	22		7.28	<0.001
	Thalamus	L/R		−6	−26	12	-	7.49
	Insula	L/R		−30	−26	16	-	6.93
	Precuneus	L		−6	−42	64	1504	5.54	<0.001
	Paracentral lobule	L		−4	−28	72	-	4.57
	Middle frontal gyrus	L		−30	40	22	122	4.7	<0.001
	Lingual gyrus	R		18	−78	10	272	4.47	<0.001
Ctl>pain
	Medial orbital	R	11	6	24	−12	129	4.38	<0.001

Abbreviations: L, left; R, right; BA, Brodmann area; MNI, Montreal Neurologic Institute.