Figure 1.

Increased body weight, decreased neuromuscular strength, increased thermal sensitivity, and decreased motor function in middle‐aged and aged C57BL/6J mice. (A) Body weight (g), (B) body temperature (°C), (C) wire hang latency (s), (D) grip strength (Newton, N), (E) latency to paw lick or foot shake (s) in the hot plate test, and (F) latency to fall off a rotating rod (s) in the rotarod test. Values are means ± SEM. Asterisks indicate significant differences between groups after Bonferroni correction for multiple comparisons (P < 0.0083)