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. 2019 Feb 27;39(2):100–118. doi: 10.1002/npr2.12052

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© 2019 The Authors. Neuropsychopharmacology Reports published by John Wiley & Sons Australia, Ltd on behalf of The Japanese Society of Neuropsychopharmacology

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Decreased locomotor activity and altered anxiety‐like behaviors in middle‐aged and old‐aged C57BL/6J mice. (A‐D) Open field test: (A) distance traveled (cm), (B) vertical activity, (C) center time (s), and (D) stereotypic counts for each 5‐minutes block of testing. (E‐H) Light/dark transition test: (E) distance traveled (cm) in the light and dark chambers, (F) number of transitions, (G) latency to enter the light chamber (s), and (H) time spent in the light chamber (s). (I‐L) Elevated plus maze test: (I) distance traveled (cm), (J) number of arm entries, (K) entries into open arms (%), and (L) time spent in open arms (%). Values are means ± SEM. Asterisks indicate significant differences between groups after Bonferroni correction for multiple comparisons (P < 0.0083)