Figure 7.

Impaired spatial memory in aged C57BL/6J mice. (A) Number of errors to first reach the target hole, (B) latency to reach the target hole, and (C) distance traveled to first reach the target hole during the training session and the reversal session of the Barnes maze test. Time spent around the target hole in the probe test 1 day (D) and 10 days (E) after the last normal training session. (F) Time spent around the target hole in the probe test 1 day after the last reversal session. In each probe trial, averaged time spent around two holes adjacent to the target one was compared to time spent around the target. Values are means ± SEM. Asterisk indicates significant differences between groups after Bonferroni correction for multiple comparisons (P < 0.0083). Daggers represent statistical significance with paired t test (P < 0.05)