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. 2019 Feb 27;39(2):100–118. doi: 10.1002/npr2.12052

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© 2019 The Authors. Neuropsychopharmacology Reports published by John Wiley & Sons Australia, Ltd on behalf of The Japanese Society of Neuropsychopharmacology

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Increased generalized fear and impaired cued fear memory in aged C57BL/6J mice. Freezing (%) in the conditioning (A), context test (B), and cued test (C). Distance traveled (cm) in the conditioning (D), context test (E), and cued test (F). Percentage of activity suppression in the context test (G), pre‐CS period of the cued test (H), and CS period of the cued test (I). Values are means ± SEM. Asterisks indicate significant differences between groups after Bonferroni correction for multiple comparisons (P < 0.0083)