Figure 1.

DHF preferentially potentiates mossy fiber‐CA3 synaptic transmission in the hippocampal excitatory circuit. A, DHF‐induced robust synaptic potentiation at the mossy fiber (MF) to CA3 synapse. DHF was applied in bath at the horizontal bar. Sample traces show averages of 15 consecutive EPSPs during baseline and at the peak of potentiation. Scale bar: 10 ms, 0.2 mV. B, Pooled data showing the effect of DHF at the MF‐CA3 synapse (n = 6). C, Small synaptic potentiation induced by DHF at the CA3 to CA1 synapse (n = 4). Scale bar: 10 ms, 0.3 mV. D, Small synaptic potentiation induced by DHF at the medial perforant path (MPP) to dentate gyrus (DG) synapse (n = 4). Scale bar: 10 ms, 0.3 mV