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. 2018 Dec 1;39(1):17–35. doi: 10.1002/npr2.12040

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© 2018 The Authors. Neuropsychopharmacology Reports published by John Wiley & Sons Australia, Ltd on behalf of The Japanese Society of Neuropsychopharmacology

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Mice in the high‐dose group exhibited higher anxiety‐like behavior in the withdrawal period. We performed the light and dark transition test during the withdrawal period (A). Distance traveled (B), time spent in the light chamber (C), total number of light/dark transitions (D), and latency to enter the light compartment (E) are shown. There was no significant difference among groups (B‐E). Mice in the high‐dose group remained in the light chamber for a significantly shorter time during the first 0‐5 minutes (F). Data are presented as means ± SEM for the indicated numbers of animals. The P values indicate the treatment effect in one‐way ANOVA or two‐way repeated measures ANOVA. The asterisk indicates a nominally significant difference for comparisons between treatment groups (P < 0.05)