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Acute effects of low‐dose fentanyl administration on mouse open field behavior. The open field test was performed on the last day of the withdrawal period following acute administration of low‐dose fentanyl (A). Time‐course of distance traveled (B), vertical activity (C), and time spent in the central area (D) are shown. No significant differences were detected among the three groups. The P values indicate treatment effect in two‐way repeated measures ANOVA
