Table 1.

Possible mechanisms implicated for anticraving actions in treating alcohol use disorder patients

Mechanism of action of anticraving drugs	Applicable drugs
Opioid modulation	Naltrexone, Nalmefene
Dopamine neurotransmission	Naltrexone, Nalmefene
Serotonin neurotransmission	Ondansetron
GABA neurotransmission	Gabapentin
Glutamate neurotransmission	Acamprosate
Blockage of GIRK channel	Ifenprodil

GABA, γ‐aminobutyric acid; GIRK channel, G protein‐activated inwardly rectifying potassium channel.