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. 2020 Jun 8;13:5057–5067. doi: 10.2147/OTT.S237474

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© 2020 Liu et al.

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Diosgenin inhibited malignant biological properties through EZH2/RhoA pathway. (A, B) Flow cytometry with PI staining was used to detect the cell cycle distribution of AGS (A) and SGC-7901 (B). (C, D) Transwell assays were performed to evaluate the migration and invasion capabilities of (C) AGS and (D) SGC-7901 cells. (E, F) Western blot assay was used to measure EZH2, RhoA/ROCK1 and EMT related proteins. *p<0.05 vs control; #p<0.05, ##p<0.01 vs diosgenin; $p<0.05, $$p<0.01 vs diosgenin+EZH2.