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. 2020 Jun 12;128(6):067010. doi: 10.1289/EHP6508

Figure 1.

Figure 1 is a workflow diagram. Metal oxide nanoparticle library (30 MeONPs) includes characteristics like size and zeta potential, cytokine production (In vitro), and oropharyngeal instillation (In vivo). The in vitro and in vivo lead to each other. Metal oxide nanoparticle library (30 MeONPs) leads to (Q) SARs, comprising a tree diagram, where X subscript 1 leads to No and X subscript 2 by including less than or equal to 3.10 and greater than 3.10, respectively. X subscript 2 leads to yes and no by including less than or equal to 1.20 and greater than 1.20, respectively, and a graph, where Y equals f (x subscript 1, x subscript 2, to x subscript n). (Q) SARs leads to experimental validation, comprising seven new MeONPs and mechanism interpretation. Quantum chemistry calculations leads to (Q) SARs using In Silico.

Schematic workflow of metal oxide nanomaterials (MeONPs) library construction, predictive modeling, mechanism interpretation, and experimental validation.