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. 2020 Jun 8;13:5145–5153. doi: 10.2147/OTT.S244853

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© 2020 Yang et al.

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Silencing of BIRC5 suppresses proliferation and induces apoptosis in lung cancer cells. (A) the expression of BIRC5 was detected after transfected with si-BIRC5 comparing with si-ctrl in A549/H1299 cells. (B) CCK-8 assay was to detect the effect of silencing of BIRC5 on A549/H1299 cells transfected with si-BIRC5 or si-ctrl. (C) Colony formation was performed to measure the effect of silencing of BIRC5 on A549/H1299 cells transfected with si-BIRC5 or si-ctrl. (D) Apoptosis was detected in A549/H1299 cells after transfection with si-BIRC5 or si-ctrl. (E) Western blot was used to detect the BIRC5 protein expression levels in A549/H1299 cells which transfection with si-BIRC5or si-trl (*P<0.05, **P<0.01).