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. 2020 Jun 8;13:5113–5122. doi: 10.2147/OTT.S243571

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© 2020 Huang et al.

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CircFoxo3 promotes cell invasion, and growth in hepatocellular carcinoma cells. (A) qRT-PCR analysis of expression levels of circFoxo3 in four HCC cell lines (SK-HEP-1,HepG2, SK-HEP-1/ADM and HepG2/ADM) and the normal cell line (HL-7702). *p < 0.05. (B) qRT-PCR analysis for circFoxo3 in HepG2/ADM and SK-HEP-1/ADM cells transfected with circFoxo3 over-expression plasmid or sh-circFoxo3 plasmid. *p < 0.05. (C) Transwell assay was performed in HepG2/ADM and SK-HEP-1/ADM cells transfected with circFoxo3 over-expression plasmid or sh-circFoxo3 plasmid. *p < 0.05. (D) BALB/c nude mice were subcutaneously injected with SK-HEP-1/ADM cells transfected with circFoxo3 over-expression plasmid or sh-circFoxo3 plasmid. The cells transfected with pCD25-ciR or scramble were used as a control for circFoxo3 over-expression plasmid or sh-circFoxo3 plasmid, respectively. Tumor volumes were measured every week. *p < 0.05. (E) The xenografted tumor weights were measured. *p < 0.05.