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. Author manuscript; available in PMC: 2020 Jun 12.
Published in final edited form as: Q Rev Biophys. 2012 Nov;45(4):493–521. doi: 10.1017/S0033583512000145

Fig. 9.

Fig. 9.

Dimeric IS608 TnpA transpososomes. (a) TnpA bound to an LE 26-mer (in red) and a 6-mer cleavage or target site (grey). The two monomers are shown in different shades of orange to illustrate the composite active site. Active site residues H64, H66, and Y127 are shown in ball-and-stick representation. PDB code: 2VJV. In this structure, Y127 has been replaced by Phe. (b) TnpA bound to a RE 35-mer (in blue). PDB code: 2VJU.