. Author manuscript; available in PMC: 2020 Jun 12.

Published in final edited form as: Gastroenterology. 2020 Mar 2;158(6):1540–1543. doi: 10.1053/j.gastro.2020.02.040

Table 1.

Summary of Characteristic Features of Peritoneal Macrophages in Ascites Fluid

	Cirrhosis			CAPD
	No SPB		SBP	No SBP
	LPM	SPM	LPM	LPM
Cell surface markers	CD14⁺, CD16⁺, CD206⁺, CD163⁺, MERTK⁺, CD40⁺, CCR2⁻	CD14⁺, CD16⁺, CD206⁻, CD163⁺, MERTK⁺, CCR2⁺,	Low CD206, Low MERTK, normal CD163	CD14⁺, CD16⁺, CD206⁺, CD163⁺, MERTK⁺, CD40⁺, CCR2⁻
Gene expression in absence of LPS	TCA cycle, gluconeogenesis (PDK2, PDK3, PDK4) genes; VSIG4 (CRIg), CD163, MARCO, MSRI (CD204), GATA-6	IL6R, LGALS3, IRAK3, BACH1, GATA-6
Gene expression response to LPS	Higher expression of interferon signaling, IL-12 signaling, IL-23 mediated signaling (IFNB1, OAS1, STAT1); Lower gene expression of tolerance mediators (IRAK3, TNF-AIP3)	IL-1 signaling, TRAIL signaling, TNF receptor signaling (IL1A, IRAK2, NFKB1, NFKB2)
TNF response to escalating doses of LPS	10–100 ng/mL	5–10 ng/mL		3–6 ng/mL

LPM, large peritoneal macrophages; LPS, lipopolysaccharide; SBP, spontaneous bacterial peritonitis; TNF, tumor necrosis factor.