Table 3.
Predictors of therapy nonadherence in MONDOAC
| Adherent | Nonadherent | OR (95% CI) | ORa (95% CI) | |
|---|---|---|---|---|
| >75 y | 568 (92) | 46 (8) | Reference | Reference |
| 60‐75 y | 507 (83) | 107 (17) | 2.6 (1.8‐3.8) | 2.5 (1.8‐3.7) |
| <60 y | 74 (67) | 36 (33) | 6.0 (3.7‐9.9) | 5.9 (3.6‐9.8) |
| Female | 471 (90) | 55 (10) | Reference | Reference |
| Male | 667 (83) | 133 (17) | 1.7 (1.2‐2.4) | 1.7 (1.2‐2.4) |
| Low education | 480 (93) | 37 (7) | Reference | Reference |
| High education | 356 (78) | 102 (22) | 3.7 (2.5‐5.6) | 2.9 (1.9‐4.4) |
| Time on VKA before switch ≥2 y | 823 (87) | 119 (13) | Reference | Reference |
| Time on VKA before switch <2 y | 328 (83) | 68 (17) | 1.4 (1.0‐2.0) | 1.26 (0.9‐1.7) |
| INR control ≤ monthly | 459 (87) | 71 (13) | Reference | Reference |
| INR control ≥ weekly | 235 (81) | 55 (19) | 1.5 (1.0‐2.2) | 1.5 (1.0‐2.2) |
| Comorbidity | 881 (88) | 116 (12) | Reference | Reference |
| No comorbidity | 263 (79) | 68 (21) | 2.0 (1.4‐2.7) | 1.5 (1.1‐2.2) |
| Consultation with MS ≥ once/year | 465 (88) | 61 (12) | Reference | Reference |
| Consultation with MS < once/year | 563 (83) | 113 (17) | 1.5 (1.1‐2.1) | 1.6 (1.1‐2.2) |
| No history of minor bleeding events on DOAC | 940 (87) | 140 (13) | Reference | Reference |
| History of minor bleeding events on DOAC | 233 (83) | 49 (17) | 1.4 (1.0‐2.0) | 1.9 (1.3‐2.8) |
| Switching own initiative | 246 (86) | 39 (14) | Reference | Reference |
| Switching advice of physician | 857 (86) | 144 (14) | 1.1 (0.7‐1.6) | 1.1 (0.7‐1.6) |
| DOAC once daily | 534 (89) | 65 (11) | Reference | Reference |
| DOAC twice daily | 634 (84) | 124 (16) | 1.6 (1.2‐2.2) | 1.9 (1.3‐2.6) |
Continuous variable denoted as mean (standard deviation), categorical variables as number (percentage).
DOAC, direct oral anticoagulant; INR, International Normalized Ratio; MONDOAC, Monitoring of direct oral anti‐coagulant; MS, medical specialist; VKA, vitamin K antagonist.
a
Adjusted for age and sex (where applicable).