Figure 2.

C‐type lectin‐like receptor 2 (CLEC‐2)–deficient mice show blood/lymphatic vessel misconnection. (A) CLEC‐2 null mice (Clec1b‐/‐) (lower E12.5 fetus), but not wild‐type mice (Clec1b+/+) (upper E12.5 fetus), showed blood‐filled lymphatic vessel due to blood/lymphatic vessel misconnection. (B) The small intestine from platelet/megakaryocyte‐specific conditional CLEC‐2–deficient mice (CLEC‐2Δplt, Clec1b flox/flox; PF4‐Cre) (right panel) and control mice (CLEC‐2 fl/fl, Clec1b flox/flox; WT) (left panel). Clec1b is a gene symbol of Clec‐2. Lymphatic vessels on the surface of the small intestine are filled with blood and showed red reticular markings in the CLEC‐2Δplt mouse. In this mouse, blood‐filled lymphatic vessels are also observed between the mesenteric artery and the vein