Table 2.

Characteristics of G2 children in each anxiety disorder trajectory group

	G2 children by anxiety disorder trajectory
	Early onset, persistent anxiety n=49 (18%)		Non-persistent anxiety n=45 (16%)		No/low anxiety n=181 (66%)
	No.	% (95% CI)	No.	% (95% CI)	No.	% (95% CI)
High risk group (G1 moderate/severe MDD)	41	84 (70–93)	37	82 (68–92)	112	62 (54–69)*,**
Parent (G1) psychiatric disorders
MDD prior to G2 birth	19	39 (25–54)	15	33 (20–49)	55	30 (24–38)
Any mood disorder, ever	41	84 (70–93)	40	89 (76–96)	118	65 (58–72)*,**
Anxiety disorder, ever	14	29 (17–43)	18	40 (26–56)	51	28 (22–35)
Alcohol or drug use disorder, ever	23	47 (33–62)	20	44 (30–60)	64	35 (28–43)
G2 characteristics
Female	33	67 (52–80)	29	64 (49–78)	83	46 (38–53)*,**
Anxiety disorder(s) in childhood†
Specific phobia	39	80 (66–90)	13	29 (16–44)**	4	2 (1–6)*,**
Social phobia	16	33 (20–48)	9	20 (10–35)	0	-
Panic disorder or agoraphobia	8	16 (7–30)	6	13 (5–27)	3	2 (0–5)*,**
OCD	7	14 (6–27)	1	2 (0–12)	2	1 (0–4)**
Separation anxiety disorder	20	41 (27–56)	25	56 (40–70)	14	8 (4–13)*,**
Generalized anxiety disorder	12	24 (13–39)	12	27 (15–42)	10	6 (3–10)*,**
More than one anxiety disorder	32	65 (50–78)	16	36 (22–51)**	3	2 (0–5)*,**
Years with anxiety in childhood		14 (13–17)		6 (4–9)**		0 (0–0)*,**
Psychiatric disorders, onset <18yrs
Any mood disorder	33	67 (52–80)	27	60 (44–74)	65	36 (29–43)*,**
MDD	24	49 (34–64)	19	42 (28–58)	44	24 (18–31)*,**
Dysthymia	17	35 (22–50)	20	44 (30–60)	41	23 (17–29)*
Disruptive disorder	20	41 (27–56)	13	29 (16–44)	56	31 (24–38)
Alcohol or drug use disorder	19	39 (25–54)	11	24 (13–40)	41	23 (17–29)**

MDD: Major depressive disorder; OCD: obsessive-compulsive disorder; G1: first generation (proband); G2: second generation

^*p-value<=0.05 compared to non-persistent trajectory

^**p-value<=0.05 compared to early/persistent trajectory

^†28 children placed in the ‘no/low anxiety’ trajectory had an anxiety disorder, duration: 1 year (n=12), 2 years (n=14), 3 years (n=2); No PTSD cases