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Schematic of the substrate (indole) transport pathway inside AcrB monomer. The pathway starts with the cleft entrance and ends at the exit gate. Channel 1 consists of cleft entrance and proximal binding pocket (PBP), while the channel 2 consists of exit gate and distal binding pocket (DBP). The relative location of important residues such as Phe676 (F676), Serine 134 (S134), and Glutamine 124 (Q124) are shown along the channel.
