Table 3.

Influence of registration and group on radiomic values. For the registration effect, negative values indicate lower average radiomic values post-registration. For the group effect, negative values indicate lower average radiomic values in healthy controls. Results are presented as mean (95% CI). Bolded results are significant at a significance threshold of 0.05.

Outcome	Registration Effect (Post- v. Pre-registration)		Group Effect (Control v. Sarcoidosis)
	Controls	Sarcoidosis	Pre-Registration	Post-Registration
Mean	−6.22 (−7.97, −4.47)	−8.69 (−9.70, −7.69)	−12.37 (−20.24, −4.51)	−9.90 (−17.76, −2.04)
SD	−18.44 (−19.74, −17.13)	−21.93 (−22.68, −21.17)	−15.94 (−20.38, −11.49)	−12.45 (−16.89, −8.01)
Skew	0.51 (0.46, 0.55)	0.46 (0.44, 0.49)	0.49 (0.34, 0.64)	0.53 (0.38, 0.68)
Kurtosis	5.93 (5.52, 6.34)	4.49 (4.26, 4.73)	4.33 (3.01, 5.65)	5.77 (4.45, 7.08)
Contrast	−4.46 (−4.70, −4.22)	−5.17 (−5.31, −5.03)	0.36 (−0.51, 1.23)	1.07 (0.20, 1.94)
Autocorrelation	2.15 (2.00, 2.30)	3.14 (3.05, 3.23)	0.09 (−0.34, 0.52)	−0.90 (−1.33, −0.47)
Energy (x1000)	1.37 (1.28, 1.45)	1.72 (1.67, 1.77)	−0.05 (−0.26, 0.17)	−0.40 (−0.61, −0.18)
Homogeneity (x100)	4.44 (4.22, 4.66)	5.21 (5.09, 5.34)	−0.15 (−0.89, 0.60)	−0.92 (−1.67, −0.17)