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Shows the number of terminal bronchioles and the mean linear intercept (Lm) in experiment 1. (A) Terminal bronchioles are sharply reduced in number per mL of tissue compared to controls in regions of minimal fibrosis, without further decline between regions of minimal and established fibrosis in IPF. (B) Lm increased in regions of established fibrosis in IPF due to the collapse of alveoli on alveolar ducts Values are expressed as per sample.
