Table 1:
Patient characteristics in experiments 1 and 2.
| Experiment 1 Random sampling |
Experiment 2 Targeted sampling |
|||
|---|---|---|---|---|
| Control | IPF | Control | IPF | |
| Patient Characteristics | ||||
| N† | 8 | 9 | 6 | 9 |
| Sex ratio M/F | 7/1 | 9/0 | 4/2 | 9/0 |
| Age | 54·0 ± 12·4 | 57·4 ± 4·8 | 57·8 ± 4·4 | 57·2 ± 5·4 |
| Height (cm) | 176 ± 6 | 171 ± 8 | 176 ± 2 | 173 ±7 |
| Weight (kg) | 81 ± 15 | 71 ± 11 | 83 ± 5 | 72 ± 10 |
| Smoking history (ex/none) | 3/5 | 8/1 | 2/4 | 9/0 |
| Pack Years | 9 ± 14 | 16 ± 12 | NA | 24 ±12 |
| Pulmonary Function | ||||
| FEV1 (% pred) | - | 59·2 ± 14·1 | - | 63·0 ± 16·8 |
| FVC (% pred) | - | 54·2 ± 14·0 | - | 58·9 ± 17·2 |
| TLC (% pred) | - | 52·4 ± 11·7 | - | 56·9 ± 16·6 |
| DLco (% pred) | - | 26·6 ± 10·24 | - | 27·3 ± 8·2 |
| FEV1/FVC | - | 0·88 ± 0·05 | - | 0·85 ± 0·06 |
| Pre-operative CT | ||||
| Airway dilatation (%) | - | 55 ± 30 | - | 50 ± 11 |
| Consolidation (%) | - | 2 ± 4 | - | 2 ± 1 |
| Ground glass opacities (%) | - | 46 ± 27 | - | 57 ± 9 |
| Air trapping (%) | - | 9 ± 4 | - | 8 ± 2 |
| Reticular pattern (%) | - | 63 ± 12 | - | 63 ± 4 |
| Volume loss (%) | - | 44 ± 18 | - | 40 ± 8 |
| Cyst formation (%) | - | 49 ± 19 | - | 53 ± 6 |
| Emphysema (%) | - | 7 ± 12 | - | 19 ± 7 |
Values given are the means ± standard deviation (SD). FEV1 denotes forced expiratory volume in 1 second, FVC forced vital capacity post-bronchodilator, and TLC total lung capacity. DLCO/VA denotes the diffusing capacity of the lung for carbon monoxide adjusted for alveolar volume. The severity of disease was graded on the pre-operative CT using the current guidelines.
†
Seven out of nine patients with IPF and three out of six control subjects in experiment 2 were also included in experiments 1.