Table 2:
Specimen MDCT and microCT analysis in experiments 1 and 2
| Experiment 1 Random sampling |
Experiment 2 Targeted sampling |
|||||
|---|---|---|---|---|---|---|
| Control (N=8) |
IPF (N=9) |
p value | Control (N = 6†) |
IPF (N = 9†) |
p value | |
| Lung specimen CT | ||||||
| Total Lung volume (L) | 3·29 ± 0·61 | 1·52 ± 0·39 | <0·0001 | 3·35± 0·44 | 1·60 ± 0·38 | 0·0004 |
| Lung tissue volume (L) | 0·403 ± 0·051 | 0·598 ± 0·106 | 0·001 | 0·369 ± 0·64 | 0·566 ± 0·140 | 0·0076 |
| Lung mass (g) | 434 ± 53 | 606 ± 117 | 0·001 | 392 ± 68 | 641 ± 125 | 0·0016 |
| Lung density (g/L) | 134 ± 16 | 407 ± 59 | <0·0001 | 118 ± 19 | 409 ± 21 | 0·0004 |
| No. airways/L of lung | 125±36 | 572±222 | <0·0001 | NA | NA | NA |
| Total no. of airways /lung | 402±114 | 811±251 | 0·0055 | NA | NA | NA |
| Micro CT | ||||||
| No. sample cores | 72 | 78 | 36 | 54 | ||
| No. terminal bronchioles /lung | 17,914 ± 6,243 | 3,404 ± 748 | <0·0001 | 13,981 ± 4,029 | 2,368 ± 1,063 | <0·001 |
| No. terminal bronchioles /mL | 5·8 ± 0·7 | 2·3 ± 0·4 | <0·0001 | 4·1 ± 1·5 | 1·7 ± 1·2 | < 0·0001 |
| Minimal Diameter (μm) | 370 ± 39 | 463 ± 59 | 0·0025 | 610 ± 149 | 671 ± 152 | 0·0480 |
| Minimal area(mm²) Parenchyma | 0·16 ± 0·02 | 0·25 ± 0·05 | 0·0002 | 0·30 ± 0·15 | 0·37 ± 0·16 | 0·0480 |
| Lm (μm) | 269 ±26 | 345 ± 54 | 0·0010 | 359 ± 53 | 523 ± 308 | 0·0001 |
| % of Tissue | 23·6 ± 1·7 | 38·3 ± 5·9 | <0·0001 | 28·4 ± 3·7 | 48·5 ± 13·3 | < 0·0001 |
Values given are the means ± standard deviation (SD). Values derived from the specimen MDCT scan and No. terminal bronchioles /lung are expressed per case, whereas other values derived from the micro CT scans are expressed per sample. Lm denotes mean linear intercept.
†
Seven patients with IPF and 3 control subjects were included in both experiments 1 and 2.