. Author manuscript; available in PMC: 2021 Jul 1.

Published in final edited form as: Trends Parasitol. 2020 May 23;36(7):634–645. doi: 10.1016/j.pt.2020.04.011

Table 2.

Characteristics of complement interacting proteins of LD spirochetes

	BBK32	OspC	CspA	CspZ	OspE paralogs			BGA66	BGA71	p43
	BBK32	OspC	CspA	CspZ	ErpP^a	ErpC^a	ErpA^a	BGA66	BGA71	p43
synonyms and other designations	none	none	CRASP-1 BBA68	CRASP-2 BBH06	CRASP-3 BBN38	CRASP-4	CRASP-5 ErpI ErpN BBP38 BBL39 OspE	none	none	none
gene name	bbk32	ospC	cspA	cspZ	erpP	erpC	erpA	bga66	bga71	ND
origin	Bb	Bb	Bb, Ba, Bs, Bm	Bb	Bb	Bb	Bb	Bba	Bba	Bb
confers serum resistance	yes	yes	yes	yes	unclear^b	unclear^b	unclear^b	yes	yes	ND
interaction with complement	C1r	C2	FH FHL-1	FH FHL-1	FHR-1 FHR-2	FHR-1 FHR-2	FHR-1 FHR-2	C7, C8, C9,	C7, C8, C9,	C4BP
regulators / components			C7, C8, C9, TCC		FHR-5		FHR-5	TCC	TCC
affected complement pathways	CP	CP	AP, TS	AP	ND	ND	ND	TS	TS	CP/LP(?)
Fed larvae	−	−	+	+ (LE)	+ (HE)	+ (HE)	+ (HE)	ND	ND	ND
Unfed nymphs	−	−	+ (HE)	−	−	−	−	ND	ND	ND
Fed nymphs	+	+	+ (LE)	+ (LE)	+	+	+	ND	ND	ND
Tick biting sites	+	+	+	+ (HE)	+ (HE)	+ (HE)	+ (HE)	ND	ND	ND
Distal sites	+	−	−	+ (HE)	+ (HE)	+ (HE)	+ (HE)	ND	ND	ND
			+	+ (LE)	+ (HE)	+ (HE)	+ (HE)	ND	ND	ND

Binding of FH has only been confirmed for recombinant proteins.

Confers serum resistance only when ErpP and ErpA are expressed under flaB promoter in a cspA-deficient B. burgdorferi in the infectious background.

CRASP, complement-regulator acquiring surface protein; Erp, OspE/F-like protein; FH, Factor H; FHL, Factor H-like protein, FHR, FH-related protein; TCC, terminal complement complex; Bb, B. burgdorferi; Bba, B. bavariensis; Ba, B. afzelii; Bs, B. spielmanii; Bm, B. mayonii; AP, alternative pathway; CP, classical pathway; LP, lectin pathway; TS, terminal sequence, ND; no data available, HE; high expression, LE; low expression