| Tacrolimus is more than 99% associated with erythrocytes. This may result in diminished whole-blood concentrations when hematocrit decreases. |
| The whole-blood to unbound plasma concentration ratios differ with changes in hematocrit and show saturation in the higher range of whole-blood tacrolimus concentrations, which may increase toxicity in these higher concentration ranges. |
| Because of the complicated bio-analytical challenges, hematocrit-corrected whole-blood concentrations may be the most feasible and suitable surrogate for the prediction of clinical outcomes. |
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