Table 3.
Tonsillectomy and risk of Parkinson's disease (PD), nationwide case-control analysis.
| N | PD cases | Controls | Model 1aa | Model 2b |
|---|---|---|---|---|
| N | OR (95% CI) | OR (95% CI)b | ||
| Tonsillectomy | ||||
| No | 78,409 (99.7) | 3,136,900 (99.7) | 1 | 1 |
| Yes | 241 (0.3) | 9,100 (0.3) | 1.06 (0.93–1.21) | 0.92 (0.81–1.04) |
| Years before index date | ||||
| <5 | 26 (0) | 954 (0) | 1.09 (0.74–1.61) | 0.91 (0.62–1.34) |
| ≥5 | 215 (0.3) | 8,146 (0.3) | 1.06 (0.92–1.21) | 0.92 (0.80–1.05) |
| <10 | 59 (0.1) | 2,014 (0.1) | 1.17 (0.90–1.52) | 0.98 (0.75–1.27) |
| ≥10 | 182 (0.2) | 7,086 (0.2) | 1.03 (0.89–1.19) | 0.90 (0.77–1.04) |
| <20 | 136 (0.2) | 4,699 (0.1) | 1.16 (0.98–1.37) | 0.98 (0.83–1.16) |
| ≥20 | 105 (0.1) | 4,401 (0.1) | 0.95 (0.79–1.16) | 0.85 (0.70–1.03) |
| Stratified by Sex | ||||
| Male | 141 (0.2) | 5,247 (0.2) | 1.08 (0.91–1.27) | 0.92 (0.78–1.09) |
| Female | 100 (0.1) | 3,853 (0.1) | 1.04 (0.85–1.27) | 0.91 (0.75–1.11) |
| Stratified by age at index date, years | ||||
| <60 | 93 (0.1) | 3,081 (0.1) | 1.21 (0.98–1.50) | 1.02 (0.83–1.26) |
| 60–69 | 63 (0.1) | 2,600 (0.1) | 0.97 (0.75–1.25) | 0.83 (0.64–1.07) |
| 70–79 | 62 (0.1) | 2,489 (0.1) | 1.00 (0.77–1.28) | 0.88 (0.68–1.13) |
| ≥80 | 23 (0) | 930 (0) | 0.99 (0.65–1.50) | 0.90 (0.60–1.36) |
a
Logistic regression conditional on birth year and sex;
b
Logistic regression conditional on birth year and sex, and additionally adjusted for country of birth, highest achieved education, COPD, comorbidity index, and number of hospital visits.