Fig. 1.

Left: Representation of the pre-processing operations performed for the definition of the vertebral body section model (cropping of the endplates in 20% of the vertebral body height). Right: Middle cross-section of the vertebral model, used to set up the position of the simulated lytic lesions in function of the distance between the geometric centre of the mid-section and the most lateral and anterior-posterior points (red crosses), and the size of the lesions. Illustration of lesions occupying 4%, 12% (orange), 24% (blue), and 35% (green) of the VBvol, placed over the lateral left compartment of the mid-cross section of the vertebral model.