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. 2020 Apr 18;37:100985. doi: 10.1016/j.molmet.2020.100985

Figure 3.

Figure 3

Partial nonspecific rescue of Pomc fails to normalize food intake and body weight. (A, B) Average of daily food intake from the 6th to 8th and from the 12th to 14th weeks of age (before (PRE) and after (POST) treatment, respectively) in female (A) and male (B) mice treated i. p. with a single low dose of tamoxifen (TAM) at P60). N = 4–7. (C, D) Body weight curves of female (C) and male (D) mice. The graphs on the right show comparisons of body weights before (PRE, 7 weeks old) and after (POST, 16 weeks old) TAM treatment. N = 4–7. (E, F) Comparison of body weights of female (E) and male (F) mice before and after GABA-specific or nonspecific Pomc rescue at P60. The data of arcPomc−/−:Gad2-CreER and Gad2-CreER phenotypes correspond to the same mice shown in Figure 2B (females) and Figure 2I (males). N = 4–14. Error bars: ±SEM. RMA: ∗P < 0.05, and ∗∗P < 0.01, ∗∗∗P < 0.001. Pre versus Post: #P < 0.05, ##P < 0.01, and ###P < 0.001 (Bonferroni).