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. 2020 Apr 18;37:100985. doi: 10.1016/j.molmet.2020.100985

Figure 4.

Figure 4

POMC fibers projecting to the dorsomedial hypothalamic nucleus (DMH) of POMC rescued mice. (A) Schematic coronal brain section adapted from [57]. The red rectangle signalizes the brain area shown in the upper pictures of (B) and (C). (B) Upper panels: representative coronal brain sections of Gad2-CreER and rescued arcPomc−/−:Gad2-CreER female mice showing POMC immunopositive neurons in the arcuate nucleus (Arc) and POMC immunoreactive fibers (POMC-IRFs) in the DMH. Magnification bars: 200 μm. (C) Upper panels: representative coronal brain sections of CreER and rescued arcPomc−/−:CreER female mice showing POMC immunopositive neurons in the Arc and POMC-IRFs in the DMH. Magnification bars: 200 μm. (B and C) Bottom panels: magnified areas of DMH taken from the upper pictures showing POMC-IRsF. Magnification bars: 50 μm.