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. 2020 Apr 18;37:100985. doi: 10.1016/j.molmet.2020.100985

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© 2020 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Model of an arcuate GABAergic-POMC → DMH-NPY circuit for the regulation of food intake. Upper panel: in wild-type mice (Pomc⁺), GABAergic-POMC neurons (red-filled circles with G) of the arcuate nucleus (Arc) suppress food intake by inhibiting NPY expression in dorsomedial hypothalamic nucleus (DMH) neurons (green open circles), maintaining a normal weight. Middle panel: in Pomc knockout mice (Pomc⁻), lack of Pomc expression in Arc neurons (red-open circles) results in DMH-NPY expression (green-filled circles) and increased food intake and obesity. Lower panel: Pomc expression restricted to GABAergic neurons (Pomc^GABA) recovers NPY inhibition resulting in normal food intake and weight loss.