Fig. 1.

The SOX9 mRNA expression in bone tumors. The SOX9 expression level was evaluated in different bone tumor tissues and its expression level was elevated in a bone tumor (a) versus normal bone tissues also malignant bone tumors versus benign tumors (b). The SOX9 expression evaluated in different types of malignant bone tumors compared to tumor margins in each group (c) and benign bone tumors normal paired tissue in each group (d). SOX9 overexpression observed in chemotherapy received patients (e), high-grade tumors (f), metastatic tumors in each malignant group (g), tumors with poor response to chemotherapy (h), and recurrent tumors (i). The Statistical differences between groups are shown as asterisk (*= P < 0.05, **= P < 0.01, ***= P < 0.001, ****= P < 0.0001).