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. 2020 May 12;48(11):5953–5966. doi: 10.1093/nar/gkaa369

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© The Author(s) 2020. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — GCN5 influences the deposition of H3K9ac through its action on H3K14ac. (A) (top) H3K9ac merged profiles of WT and gcn5-1 mutant, restricted to genes that are both GNC5 targets and down-regulated in the mutant. (bottom) H3K27me3 merged profiles of WT and gcn5-1 mutant, restricted to genes that are both GNC5 targets and down-regulated in the mutant. Mean-normalized ChIP-Seq densities of equal bins along the gene and 2kb region flanking the TSS and the TES were plotted. (B) (top) H3K9ac merged profiles of WT and gcn5-1 mutant, restricted to genes that are both GNC5 targets and up-regulated in the mutant. (bottom) H3K27me3 merged profiles of WT and gcn5-1 mutant, restricted to genes that are both GNC5 targets and up-regulated in the mutant. The blue shading highlights the 3′ end part where H3K14ac hyperacetylation is observed on the same set of genes. Mean-normalized ChIP-Seq densities of equal bins along the gene and 2 kb region flanking the TSS and the TES were plotted. (C) (top) H3K14ac merged profiles of WT and gcn5-1 mutant, restricted to genes that are both GNC5 targets and not differentially expressed in the mutant. (middle) H3K9ac merged profiles of WT and gcn5-1 mutant, restricted to genes that are both GNC5 targets and not differentially expressed in the mutant. (bottom) H3K27me3 merged profiles of WT and gcn5-1 mutant, restricted to genes that are both GNC5 targets and not differentially expressed in the mutant. The blue shading highlights the 3′ end part where H3K14ac hyperacetylation is observed. Mean-normalized ChIP-Seq densities of equal bins along the gene and 2kb region flanking the TSS and the TES were plotted.