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. 2020 May 11;48(11):5873–5890. doi: 10.1093/nar/gkaa321

Figure 5.

Figure 5.

Lineage-specific chromatin dynamics of Satb1 alternative promoter regions during thymic T-cell development from precursor cells. (A) We used publicly available ATAC-seq data from HSCs, MPPs, CLPs, B cells and T cells to analyze the state of chromatin accessibility at the alternative promoters of the Satb1 gene locus in these cell types. Satb1 alternative promoter regions (P1, P2, P3 and P4) are marked by rectangular boxes at the Satb1 gene locus. (B) We analyzed the publicly available ATAC-seq datasets performed in various T-cell developmental stages; DN1, DN2a, DN2b, DN3, DN4, DP, CD4SP and CD8SP to assess the chromatin dynamics at the alternative promoters of the Satb1 gene locus. We also used ATAC-seq data from naïve CD4 and CD8 populations alongside the developmental stages. The distinct Satb1 alternative promoter regions (P1, P2, P3 and P4) are marked by rectangular boxes at the Satb1 gene locus.