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Roles of the PvrA regulated genes in the bacterial virulence. The indicated strains were grown in LB to an OD600 of 1.0. Mice were infected intranasally with 4 × 106 CFU of each strain. The mice were sacrificed 12 hpi and the bacterial loads in the lungs were determined by plating. Bars represent medians, and error bars represent standard deviations. ***P < 0.001 by Student's t-test.
