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Proposed molecular pathway for tumor‐associated macrophage (TAM)‐stimulated glycerol‐3‐phosphate dehydrogenase (GPD2) activation in glioma cells. TAM release interleukin (IL)‐1β, which triggers phosphorylation of GPD2 at T10 in glioma cells via PKCδ. This action induces a shift to glycolytic metabolism, which stimulates cellular proliferation and gliomagenesis
