Table 1.
Association of clinicopathological features and programmed death ligand‐1 (PD‐L1) expression, CD8 expression, and hot tumor immune status in 41 esophageal squamous cell carcinoma (ESCC) patients
| Factor | PD‐L1 expression | P value | CD8 expression | P value | Tumor immune status | P value | |||
|---|---|---|---|---|---|---|---|---|---|
| Low (n = 19) | High (n = 22) | Low (n = 27) | High (n = 14) | Hot tumor (high PD‐L1/high CD8, n = 13) | Others (n = 28) | ||||
| Age (y) | |||||||||
| Mean ± SD | 67.7 ± 7.1 | 65.6 ± 6.3 | .32 | 67.0 ± 6.8 | 65.9 ± 6.7 | .64 | 65.4 ± 6.6 | 67.2 ± 6.7 | .43 |
| Sex | |||||||||
| Male | 15 | 21 | .11 | 23 | 13 | .48 | 12 | 24 | .55 |
| Female | 4 | 1 | 4 | 1 | 1 | 4 | |||
| Tumor invasion | |||||||||
| T1, T2 | 15 | 10 | .028 | 17 | 8 | .717 | 7 | 18 | .524 |
| T3, T4 | 4 | 12 | 10 | 6 | 6 | 10 | |||
| N factor | |||||||||
| Absent | 9 | 5 | .097 | 9 | 5 | .879 | 4 | 10 | .756 |
| Present | 10 | 17 | 18 | 9 | 9 | 18 | |||
| Lymphatic invasion | |||||||||
| Absent | 7 | 2 | .032 | 6 | 3 | .954 | 2 | 7 | .489 |
| Present | 12 | 20 | 21 | 11 | 11 | 21 | |||
| Venous invasion | |||||||||
| Absent | 9 | 3 | .018 | 9 | 3 | .427 | 3 | 9 | .553 |
| Present | 10 | 19 | 18 | 11 | 10 | 19 | |||
| Stage | |||||||||
| Stage I, II | 13 | 8 | .041 | 15 | 6 | .441 | 5 | 16 | .266 |
| Stage III, IV | 6 | 14 | 12 | 8 | 8 | 12 | |||
| PD‐L1 expression | |||||||||
| Low | – | – | – | 18 | 1 | <.001 | – | – | – |
| High | – | – | 9 | 13 | – | – | |||
| CD8 positive lymphocytes | |||||||||
| Low | 18 | 9 | <.001 | – | – | – | – | – | – |
| High | 1 | 13 | – | – | – | – | |||
| GLUT1 | |||||||||
| Low | 11 | 2 | <.001 | 11 | 2 | .084 | 1 | 12 | .024 |
| High | 8 | 20 | 16 | 12 | 12 | 16 | |||
| LAT1 | |||||||||
| Low | 15 | 8 | .006 | 16 | 7 | .571 | 6 | 17 | .382 |
| High | 4 | 14 | 11 | 7 | 7 | 11 | |||
| Ki‐67 labeling index | |||||||||
| Mean ± SD | 36.8 ± 19.2 | 52.4 ± 17.6 | .009 | 39.1 ± 18.2 | 56.7 ± 17.8 | .005 | 56.1 ± 18.3 | 40.1 ± 18.6 | .014 |
| CD34 positive vessels counts | |||||||||
| Mean ± SD | 13.9 ± 5.3 | 22.1 ± 5.9 | <.001 | 17.0 ± 7.0 | 21.0 ± 6.0 | .075 | 20.9 ± 6.2 | 17.1 ± 7.0 | .103 |