TABLE 2.
Disease‐free survival of intraepithelial and stromal lymphocyte subsets and their ratios in the total cohort
| High | Low | Log‐rank | |||
|---|---|---|---|---|---|
| Median (d) | (95% CI) | Median (d) | (95% CI) | P‐value | |
| CD8 | |||||
| Tumor islets | |||||
| Max | 58.88 | 0.00‐210.6 | 21.60 | 10.93‐32.27 | 0.217 |
| Med | 145.20 | 20.75‐269.65 | 16.50 | 6.16‐26.84 | 0.037 |
| Mean | 39.85 | 17.10‐173.30 | 5.28 | 6.16‐26.84 | 0.074 |
| Stromal | |||||
| Max | 95.50 | 0.00‐195.40 | 14.60 | 6.79‐22.41 | 0.034 |
| Med | 145.20 | 72.17‐218.23 | 14.60 | 8.34‐20.86 | 0.004 |
| Mean | 145.20 | 16.13‐274.27 | 14.60 | 8.34‐20.86 | 0.004 |
| CD20 | |||||
| Tumor islets | |||||
| Max | 23.40 | 0.00‐144.32 | 27.80 | 3.89‐51.72 | 0.565 |
| Med | 109.70 | 70.09‐149.31 | 20.70 | 7.24‐34.16 | 0.027 |
| Mean | 23.40 | 0.00‐144.32 | 27.80 | 3.89‐51.72 | 0.565 |
| Stromal | |||||
| Max | 145.20 | 0.00‐352.56 | 19.30 | 6.08‐32.52 | 0.002 |
| Med | 109.70 | 0.00‐231.80 | 21.60 | 5.31‐37.89 | 0.096 |
| Mean | 145.20 | 0.00‐352.56 | 19.30 | 6.08‐32.52 | 0.002 |
| CD204 | |||||
| Tumor islets | |||||
| Max | 45.70 | 0.00‐137.72 | 23.40 | 14.12‐32.68 | 0.617 |
| Med | 95.20 | 19.78‐170.62 | 21.60 | 10.56‐32.64 | 0.046 |
| Mean | 95.20 | 6.77‐183.62 | 23.40 | 14.38‐32.42 | 0.122 |
| Stromal | |||||
| Max | 23.90 | 15.10‐32.70 | 38.80 | 0.00‐79.08 | 0.957 |
| Med | 20.70 | 5.22‐36.18 | 95.20 | 2.09‐188.31 | 0.275 |
| Mean | 23.90 | 15.82‐31.98 | 49.40 | 0.00‐104.63 | 0.632 |
| FOXP3 | |||||
| Tumor islets | |||||
| Max | 109.70 | 15.34‐204.07 | 23.40 | 18.36‐28.44 | 0.108 |
| Med | 109.70 | 0.00‐296.41 | 23.90 | 14.26‐33.54 | 0.480 |
| Mean | 109.70 | 15.34‐204.07 | 23.40 | 18.36‐28.44 | 0.108 |
| Stromal | |||||
| Max | 145.20 | 1.67‐288.73 | 19.30 | 6.05‐32.56 | 0.030 |
| Med | 109.70 | 29.78‐189.63 | 19.30 | 9.35‐29.25 | 0.060 |
| Mean | 145.20 | 1.58‐288.82 | 19.30 | 9.35‐29.25 | 0.022 |
| CD8/204 | |||||
| Tumor islets | |||||
| Max | 38.80 | 0.00‐110.79 | 19.30 | 6.32‐32.29 | 0.341 |
| Med | 95.20 | 4.78‐185.62 | 19.30 | 5.843‐32.757 | 0.066 |
| Mean | 95.20 | 0.00‐203.97 | 19.30 | 5.84‐32.76 | 0.162 |
| Stromal | |||||
| Max | 95.20 | 0.00‐197.577 | 21.60 | 10.63‐32.57 | 0.406 |
| Med | 145.20 | 15.94‐274.46 | 16.50 | 6.04‐26.96 | 0.016 |
| Mean | 95.20 | 1.60‐188.80 | 12.60 | 4.56‐20.64 | 0.029 |
| CD20/204 | |||||
| Tumor islets | |||||
| Max | 45.70 | 0.00‐162.09 | 21.60 | 11.52‐31.68 | 0.277 |
| Med | 95.20 | 0.00‐194.952 | 20.70 | 7.24‐34.16 | 0.029 |
| Mean | 45.70 | 0.00‐162.09 | 21.60 | 11.52‐31.68 | 0.283 |
| Stromal | |||||
| Max | 145.20 | 39.73‐250.67 | 12.60 | 7.56‐17.64 | 0.02 |
| Med | 109.70 | 31.88‐187.52 | 14.60 | 4.13‐25.01 | 0.03 |
| Mean | 145.20 | 80.82‐209.58 | 12.60 | 7.560‐17.640 | <0.01 |
Abbreviation: CI, confidence interval.