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Details of driver gene mutations in 50 patients with pancreatic ductal adenocarcinoma
| Parameter | KRAS (n = 42) | TP53 (n = 31) | SMAD4 (n = 16) | CDKN2A (n = 9) |
|---|---|---|---|---|
| Mutation, n (%) | ||||
| Missense | 42 (100.0) | 25 (80.6) | 9 (56.3) | 5 (55.6) |
| Nonsense | 0 (0.0) | 4 (12.9) | 4 (25.0) | 3 (33.3) |
| Frameshift insertion | 0 (0.0) | 1 (3.2) | 2 (12.5) | 0 (0.0) |
| Frameshift deletion | 0 (0.0) | 1 (3.2) | 1 (6.3) | 1 (11.1) |
| KRAS mutant subtype, n (%) | ||||
| G12D | 20 (47.6) | |||
| G12V | 15 (35.7) | |||
| G12R | 4 (9.5) | |||
| Q61H | 3 (7.1) | |||
