Table 2.
Patient characteristics by genetic test results among young women diagnosed with breast cancer at Columbia University Irving Medical Center, New York, NY (2007–2017)
| Characteristic | Genetic test result: Positive N (%)1 N = 87 (12.7%) |
Genetic test result: VUS N (%)1 N = 95 (13.9%) |
Genetic test result: Negative N (%)1 N = 501 (73.4%) |
Total N (%)2 N = 6833 |
p value |
|---|---|---|---|---|---|
| Age at diagnosis (years) | |||||
| Mean (SD) | 40.6 (6.5) | 41.4 (6.3) | 41.9 (5.8) | 41.7 (6.0) | 0.150 |
| Race/ethnicity, N (%) | |||||
| Non-Hispanic White | 45 (16.3) | 24 (8.7) | 207 (75.0) | 276 (40.4) | |
| Non-Hispanic Black | 16 (18.2) | 12 (13.6) | 60 (68.2) | 88 (12.9) | |
| Hispanic | 15 (7.9) | 36 (19.0) | 138 (73.0) | 189 (27.7) | |
| Asian | 6 (8.2) | 16 (21.9) | 51 (69.9) | 73 (10.7) | |
| Other | 5 (8.8) | 7 (12.3) | 45 (78.9) | 57 (8.3) | 0.003 |
| Marital status, N (%) | |||||
| Married | 34 (11.4) | 33 (11.1) | 231 (77.5) | 298 (43.6) | |
| Unmarried | 53 (13.8) | 62 (16.1) | 270 (70.1) | 385 (56.4) | 0.091 |
| Insurance, N (%) | |||||
| Private | 55 (13.1) | 57 (13.6) | 307 (73.3) | 419 (61.3) | |
| Medicare | 3 (7.1) | 3 (7.1) | 36 (85.7) | 42 (6.1) | |
| Medicaid | 21 (13.0) | 19 (11.8) | 121 (75.2) | 161 (23.6) | |
| Uninsured/other | 8 (13.1) | 16 (26.2) | 37 (60.7) | 61 (8.9) | 0.037 |
| Stage, N (%) | |||||
| 0 | 7 (7.6) | 7 (7.6) | 78 (84.8) | 92 (13.5) | |
| 1 | 36 (14.0) | 33 (12.8) | 189 (73.3) | 258 (37.8) | |
| 2 | 30 (13.9) | 39 (18.1) | 147 (68.1) | 216 (31.6) | |
| 3 | 7 (12.1) | 8 (13.8) | 43 (74.1) | 58 (8.5) | |
| 4 | 3 (8.6) | 5 (14.3) | 27 (77.1) | 35 (5.1) | |
| Unknown | 4 (16.7) | 3 (12.5) | 17 (70.8) | 24 (3.5) | 0.342 |
| Family history of breast cancer, N (%) | |||||
| Yes | 31 (15.4) | 28 (13.9) | 142 (70.6) | 201 (29.4) | |
| No | 56 (11.6) | 67 (13.9) | 359 (74.5) | 482 (70.6) | 0.344 |
| Year of diagnosis, N (%) | |||||
| Prior to 2008 | 6 (9.8) | 5 (8.2) | 50 (82.0) | 61 (8.9) | |
| 2008–2010 | 13 (15.9) | 8 (9.8) | 61 (74.4) | 82 (12.0) | |
| 2011–2013 | 21 (9.6) | 9 (4.1) | 188 (86.2) | 218 (31.9) | |
| After 2013 | 47 (14.6) | 72 (22.7) | 202 (62.7) | 322 (47.1) | < .001 |
Entries in italics indicate statisticially significant variables
1 Row percentages
2 Column percentages
3 Excludes 12 patients- had genetic testing but no documentation of the results in their medical record