Gene networks with transcriptional bursting recapitulate rare transient coordinated high expression states in cancer

. Author manuscript; available in PMC: 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22;10(4):363–378.e12. doi: 10.1016/j.cels.2020.03.004

Chemical reaction	Reaction propensity
I → A	$(r_{o n} + r_{a d d} \cdot \frac{{mRNA}_{X}^{n}}{k^{n} + {mRNA}_{X}^{n}}) \cdot I$
A → I	r_off · A
I → I + mRNA	r_prod · I
A → A + mRNA	d · r_prod · A
mRNA → ∅	r_deg · mRNA