Table 2. The measured distance between selected residues in NBDs and ECLs.
Position | Residue | Measured distance (Å) | ||
---|---|---|---|---|
P-gpSECO | P-gpVerapamil | ApoP-gp | ||
NBDs | R1043-D558 | 18.15 | 20.7 | 35 |
C427-C1070 | 21.8 | 27.8 | 37 | |
TM3-TM4 | G187-G226 | 13.9 | 14.5 | 16.2 |
ECL | P741-N90 | 18.77 | 28.33 | 32.26 |
Q962-N90 | 11.63 | 10.15 | 8.79 | |
I848-N90 | 25.95 | 26.77 | 29.37 | |
P741-Y849 | 24.52 | 24.82 | 26 | |
Q962-Y849 | 15.35 | 20.35 | 21.58 |
Note:
NBD, nucleotide-binding domain; ECL, extracellular loop; P-gp, P-glycoprotein; SECO, secoisolariciresinol; ApoP-gp, empty form of P-glycoprotein without binding to any ligand; TM, transmembrane.