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. 2020 Jun 10;8:e9163. doi: 10.7717/peerj.9163

Table 2. The measured distance between selected residues in NBDs and ECLs.

Position Residue Measured distance (Å)
P-gpSECO P-gpVerapamil ApoP-gp
NBDs R1043-D558 18.15 20.7 35
C427-C1070 21.8 27.8 37
TM3-TM4 G187-G226 13.9 14.5 16.2
ECL P741-N90 18.77 28.33 32.26
Q962-N90 11.63 10.15 8.79
I848-N90 25.95 26.77 29.37
P741-Y849 24.52 24.82 26
Q962-Y849 15.35 20.35 21.58

Note:

NBD, nucleotide-binding domain; ECL, extracellular loop; P-gp, P-glycoprotein; SECO, secoisolariciresinol; ApoP-gp, empty form of P-glycoprotein without binding to any ligand; TM, transmembrane.