Table 1. Significant host genes in SARS-CoV-2 infection.
List of 31 differentially expressed genes in SARS-CoV-2 infection showing consistent expression pattern in A549 and NHBE cell types. The pro-viral factors are highlighted by cell shading.
| Sl. No. | Symbol | Gene name | A549 | NHBE | Meta-analysis | |||
|---|---|---|---|---|---|---|---|---|
| log2FC | Adj. P | log2FC | Adj. P Val. | Combined effect size | P-val | |||
| 1 | IFI6 | interferon alpha inducible protein 6 | 3.4726 | 2.20E−285 | 0.4910 | 9.25E−03 | 0.8919 | 2.64E−03 |
| 2 | IFIT1 | interferon induced protein with tetratricopeptide repeats 1 | 3.0171 | 1.33E−164 | 0.5381 | 1.24E−02 | 1.9102 | 2.66E−07 |
| 3 | MX1 | MX dynamin like GTPase 1 | 3.1067 | 1.05E−158 | 1.7708 | 5.10E−34 | 1.3564 | 5.01E−05 |
| 4 | IRF9 | interferon regulatory factor 9 | 1.8037 | 1.65E−83 | 1.1033 | 5.56E−26 | 1.8136 | 1.80E−07 |
| 5 | IRF7 | interferon regulatory factor 7 | 2.1793 | 1.35E−79 | 0.7363 | 1.76E−04 | 1.0570 | 1.15E−03 |
| 6 | OAS1 | 2′-5′-oligoadenylate synthetase 1 | 1.3695 | 1.18E−65 | 1.2423 | 1.99E−17 | 0.8506 | 6.66E–03 |
| 7 | OAS3 | 2′-5′-oligoadenylate synthetase 3 | 1.2382 | 1.85E−55 | 1.1097 | 1.93E−20 | – | – |
| 8 | DTX3L | deltex E3 ubiquitin ligase 3L | 1.1582 | 3.05E−34 | 0.3844 | 2.84E−03 | – | – |
| 9 | IFIT3 | interferon induced protein with tetratricopeptide repeats 3 | 1.3826 | 9.21E−32 | 0.5429 | 3.26E−03 | – | – |
| 10 | IFIH1 | interferon induced with helicase C domain 1 | 1.2169 | 7.46E−23 | 0.5538 | 2.43E−04 | 1.2175 | 3.67E−04 |
| 11 | IFI27 | interferon alpha inducible protein 27 | 1.2853 | 2.45E−22 | 1.1013 | 9.88E−11 | 1.5037 | 2.34E−07 |
| 12 | PLSCR1 | phospholipid scramblase 1 | 0.9179 | 1.85E−22 | 0.7025 | 2.22E−07 | 0.8592 | 8.45E−03 |
| 13 | SAMHD1 | SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 | 0.8025 | 1.39E−14 | 0.5916 | 9.18E−04 | – | – |
| 14 | CFB | complement factor B | 0.8597 | 6.60E−14 | 1.5625 | 2.80E−41 | – | – |
| 15 | C1S | complement C1s | 0.6360 | 5.81E−13 | 0.5241 | 1.70E−02 | – | – |
| 16 | OAS2 | 2′-5′-oligoadenylate synthetase 2 | 0.7404 | 5.53E−09 | 1.0724 | 1.40E−19 | 0.7975 | 6.80E−03 |
| 17 | IFITM1 | interferon induced transmembrane protein 1 | 0.6736 | 8.72E−08 | 1.0275 | 8.18E−10 | 0.8890 | 6.18E−03 |
| 18 | CXCL2 | C-X-C motif chemokine ligand 2 | 0.5591 | 4.12E−07 | 1.1055 | 1.85E−16 | 4.1305 | 0.00E+00 |
| 19 | IFI44 | interferon induced protein 44 | 0.5678 | 4.09E−06 | 0.7175 | 3.88E−07 | 1.2257 | 1.02E−04 |
| 20 | TYMP | thymidine phosphorylase | 0.5890 | 5.64E−06 | 0.7536 | 5.59E−06 | – | – |
| 21 | PTGS2 | prostaglandin-endoperoxide synthase 2 | 0.5111 | 5.26E−05 | 0.4438 | 9.36E−03 | 1.7201 | 1.46E−08 |
| 22 | IFITM3 | interferon induced transmembrane protein 3 | 0.5781 | 1.32E−04 | 0.6595 | 3.63E−07 | – | – |
| 23 | BCL2A1 | BCL2 related protein A1 | 0.5339 | 1.44E−03 | 1.1167 | 1.07E−10 | 0.9892 | 3.70E−04 |
| 24 | CXCL3 | C-X-C motif chemokine ligand 3 | 0.4599 | 1.44E−03 | 1.2931 | 4.08E−15 | 2.3068 | 1.71E−10 |
| 25 | SERPINA3 | serpin family A member 3 | 0.4451 | 4.84E−03 | 1.1934 | 1.13E−20 | – | – |
| 26 | XAF1 | XIAP associated factor 1 | 0.3157 | 5.75E−03 | 1.2454 | 1.83E−13 | 1.2515 | 7.89E−05 |
| 27 | ASS1 | argininosuccinate synthase 1 | 0.3673 | 8.11E−03 | 0.4619 | 4.14E−05 | – | – |
| 28 | EDN1 | endothelin 1 | 0.3148 | 8.45E−03 | 0.8201 | 3.97E−08 | 1.0609 | 1.32E−03 |
| 29 | UBE2L6 | ubiquitin conjugating enzyme E2 L6 | 0.63038 | 3.76E−09 | 0.35748 | 0.019644 | – | – |
| 30 | IFNGR1 | interferon gamma receptor 1 | 0.38229 | 0.015405 | 0.36279 | 0.017155 | – | – |
| 31 | CDCP1 | CUB domain containing protein 1 | 0.33301 | 0.012564 | 0.34665 | 0.0012701 | – | – |