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. 2020 Jun 10;8:e9357. doi: 10.7717/peerj.9357

Table 3. Repurposable drugs from DrugBank.

List of drugs targeting pro-viral factors from DrugBank.

Protein DrugBank ID Name Drug group Pharmacological action Actions tau_score Therapy area
CFB DB02459 4-guanidinobenzoic acid experimental unknown – not available
DB04491 Diisopropylphosphono Group experimental unknown – not available
PTGS2 DB00159 Icosapent approved, nutraceutical Yes Inhibitor 16.07 Treating for depression
DB00480 Lenalidomide approved unknown negative modulator −75.35 maintenance therapy (anti-inflammatory drug)
DB00482 Celecoxib approved, investigational Yes Inhibitor −78.25 anti-inflammatory drug
DB00605 Sulindac approved, investigational Yes Inhibitor 69.63 anti-inflammatory agent
DB00712 Flurbiprofen approved, investigational Yes Inhibitor 10.62 Nonsteroidal anti-inflammatory drugs
DB00784 Mefenamic acid approved Yes Inhibitor 86.16 Nonsteroidal anti-inflammatory drugs
DB00812 Phenylbutazone approved, vet_approved Yes Inhibitor −59.87 nonsteroidal anti-inflammatory drug
DB00991 Oxaprozin approved Yes Inhibitor −25.36 nonsteroidal anti-inflammatory drug
DB00244 Mesalazine approved Yes Inhibitor 27.96 aminosalicylate and anti-inflammatory.
DB00316 Acetaminophen approved Yes Inhibitor – opioid pain medication
DB00328 Indomethacin approved, investigational Yes Inhibitor – nonsteroidal anti-inflammatory drug
DB00461 Nabumetone approved Yes Inhibitor 76.11 nonsteroidal anti-inflammatory drug
DB00465 Ketorolac approved Yes Inhibitor 39.76 nonsteroidal anti-inflammatory drug
DB00469 Tenoxicam approved Yes Inhibitor −78.71 antiinflammatory agent with analgesic and antipyretic properties
DB00500 Tolmetin approved Yes Inhibitor 94.88 nonsteroidal anti-inflammatory drug
DB00573 Fenoprofen approved Yes Inhibitor – antiinflammatory and antipyretic properties
DB00586 Diclofenac approved, vet_approved Yes Inhibitor −44.57 nonsteroidal anti-inflammatory drug
DB00749 Etodolac approved, investigational, vet_approved Yes inhibitor 49.63 anti-inflammatory agent with analgesic and antipyretic properties
DB00788 Naproxen approved, vet_approved Yes inhibitor −72.61 nonsteroidal anti-inflammatory drug
DB00814 Meloxicam approved, vet_approved Yes inhibitor 16.48 nonsteroidal anti-inflammatory drug
DB00861 Diflunisal approved, investigational Yes inhibitor −15.47 anti-inflammatory and antipyretic properties
DB00939 Meclofenamic acid approved, vet_approved Yes inhibitor −85.24 nonsteroidal agent
DB00945 Acetylsalicylic acid approved, vet_approved Yes inhibitor – Cardiovascular
DB00963 Bromfenac approved Yes inhibitor 66.6 nonsteroidal anti-inflammatory drug (NSAID)
DB01009 Ketoprofen approved, vet_approved Yes inhibitor −45.36 nonsteroidal anti-inflammatory agent (NSAIA)
DB01014 Balsalazide approved, investigational Yes inhibitor −63.18 anti-inflammatory drug
DB01050 Ibuprofen approved Yes inhibitor 96.49 non-steroidal anti-inflammatory drug (NSAID)
DB01283 Lumiracoxib approved, investigational Yes inhibitor – nonsteroidal anti-inflammatory drug.
DB01399 Salsalate approved Yes inhibitor – nonsteroidal anti-inflammatory drug.
DB00936 Salicylic acid approved, investigational, vet_approved Yes inhibitor – non-steroidal anti-inflammatory drug (NSAID)
DB01041 Thalidomide approved, investigational, withdrawn unknown antagonist 23.43 Immunomodulatory drug
DB01404 Ginseng approved, investigational, nutraceutical unknown inhibitor – not available
DB01628 Etoricoxib approved, investigational Yes inhibitor – non-steroidal anti-inflammatory drugs
DB01600 Tiaprofenic acid approved Yes inhibitor 33.41 non-steroidal anti-inflammatory drug
DB02266 Flufenamic acid approved unknown −62.8 not available
DB00554 Piroxicam approved, investigational Yes inhibitor −71.6 nonsteroidal anti-inflammatory drugs (NSAIDs)
DB00250 Dapsone approved, investigational unknown substrate −61.99 anti-inflammatory immunosuppressive properties as well as antibacterial and antibiotic properties
DB06725 Lornoxicam approved, investigational Yes inhibitor – non-steroidal anti-inflammatory drug (NSAID)
DB06802 Nepafenac approved, investigational unknown inhibitor – non-steroidal anti-inflammatory drug (NSAID)
DB00795 Sulfasalazine approved Yes inhibitor −93.8 anti-inflammatory drug
DB01435 Antipyrine approved, investigational unknown inhibitor – analgesic and antipyretic
DB01419 Antrafenine approved unknown inhibitor – anti-inflammatory effect
DB01401 Choline magnesium trisalicylate approved unknown inhibitor – non-steroidal anti-inflammatory drug (NSAID)
DB00233 Aminosalicylic acid approved unknown inhibitor – anti-mycobacterial agent
DB00963 Bromfenac approved unknown inhibitor 66.6 non-steroidal anti-inflammatory drug (NSAID)
DB00887 Bumetanide approved unknown inducer 61.14 Cardiovascular
DB06774 Capsaicin approved unknown inhibitor 39.94 anti-fungal agent
DB00856 Chlorphenesin approved, experimental unknown inhibitor – antifungal and some antibacterial properties
DB00720 Clodronic acid approved, investigational, vet_approved unknown inhibitor – antihypercalcemic agent
DB00035 Desmopressin approved unknown inducer – analgesic effect
DB01395 Drospirenone approved unknown inhibitorinducer – antiandrogen effects
DB00515 Cisplatin approved unknown inhibitor – chemotherapy medication
DB00884 Risedronic acid approved, investigational unknown inducer –
DB00360 Sapropterin approved, investigational unknown inducer – Cardiovascular
DB00041 Aldesleukin approved unknown inducer –
DB00620 Triamcinolone approved, vet_approved unknown inhibitor 87.19 generic medication.
DB08819 Tafluprost approved unknown inducer –
DB08910 Pomalidomide approved Yes inhibitor –
DB00773 Etoposide approved unknown substrate 98.52
DB08439 Parecoxib approved Yes inhibitor 20.25
DB09213 Dexibuprofen approved, investigational Yes inhibitor –
DB11133 Omega-3 fatty acids approved, nutraceutical unknown substrate –
DB06736 Aceclofenac approved, investigational Yes inhibitor –
DB13783 Acemetacin approved, investigational Yes antagonist –
DB09212 Loxoprofen approved Yes antagonist −80.04 non-steroidal anti-inflammatory drug
DB09216 Tolfenamic acid approved, investigational Yes antagonist – non-steroidal anti-inflammatory drug
DB09214 Dexketoprofen approved, investigational unknown antagonist 99.54 non-steroidal anti-inflammatory drug
DB09214 Dexketoprofen approved, investigational unknown inhibitor 99.54 non-steroidal anti-inflammatory drug
DB11079 Trolamine salicylate approved Yes inhibitor –
DB11071 Phenyl salicylate approved unknown antagonist –
DB11327 Dipyrithione approved unknown –
DB13961 Fish oil approved, nutraceutical Yes inhibitor –
DB11323 Glycol salicylate approved Yes antagonist –
DB11201 Menthyl salicylate approved Yes antagonist –
DB00210 Adapalene approved Yes inhibitor –
DB09061 Cannabidiol approved, investigational unknown inhibitor –
ASS1 DB00128 Aspartic acid approved, nutraceutical unknown –
DB00155 Citrulline approved, investigational, nutraceutical unknown –
IFNGR1 DB00033 Interferon gamma-1b approved, investigational yes binder – Chronic granulomatous disease and Osteopetrosis