Table 2:

Using gene mania and PubMed data mining, we identified genes that are related to heart function. The overall function of the gene is displayed and that which is related to either cardiac development or function.

Gene Name	Gene Function	Publication(s)related to cardiovascular function	Reference
Abcc	Multidrug resistance. Defense against toxins	Cardiac remodeling after myocardial infarction	[34,35]
Atp2b1	ATPase Ca++ transporter	Vasoconstriction and hypertension	[36]
BMP6	Mesoderm morphogenesis	Developing in endocardial cushion	[37]
Ccnd1	Cell cycle maintenance	Adult cardiomyocytes reentrance into cell cycle	[38]
Cdc73	Regulation of mRNA	Heart morphogenesis	[39]
Gna13	G-protein receptor signal	Vasculogenesis	[40]
Hccs	Activation of respiratory cytochromes	Mitochondrial respiration	[41]
Hif3α	Hypoxia dependent Transcription regulation	Angiogenesis/outflow tract development	[42]
Igf1r	Cellular response to insulin stimulus	Cardiac hypertrophy	[43]
Kif15	Microtubule cytoskeleton organization	None reported	[44]
Limk1	Actin polymerization	Reduced sarcomere structure and contractility	[45]
Lrp6	Wnt signaling pathway	Outflow tracts and valve formation	[46]
Mospd3	Cardiac muscle tissue development	Right Ventricle morphogenesis	[47]
Mt1	Metal ion homeostasis	Pressure overload and myocardial dysfunction	[48]
Osr1	Connective tissue development	Atria and septal development	[49]
Rad50	DNA repair	Expressed in adult myocardium	[50]
Rrad	Cardiac muscle	Congestive heart failure	[51]
RunX2	Regulation of ossification	Interstitial cells in aortic valve stenosis	[51]
Serping1	Protein activation cascade	Reperfusion after ischemia of heart	[52]
Slmap	Lymphocyte proliferation	Excitation-contraction coupling	[53]
Tgtp2	T cell activation	Unknown	[54]
Tnnt1	Contractile fiber development	Ventricular muscle development	[55]
Wif1	Wnt inhibitory signaling	Cardiomyocyte differentiation	[56]
Pitx2	Embryonic organ morphogenesis	Cardiac outflow tract remodeling	[57]
Ttn1	Contractile fiber	Myocardial contractility	[58]
Pdgfra	Platelet growth factor	Left ventricular thickening and thrombus	[59]
Adrb 1	Adrenergic receptor signaling	Cardiac remodeling	[60]
BMPr1b	Limb morphogenesis	myocardial intracellular calcium regulation	[61]
Actc 1	Contractile fiber	Heart contraction	[62]
Fhl2	Development and maintenance of cardiovascular and skeletal systems	Regulation of angiogenesis	[63]
Bmp10	Cardiac muscle tissue development	Cardiac contractility	[64]
Myh10	Voltage-gated channel activity	Heart development and body formation	[29]