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. 2020 Jun 12;22(4):85. doi: 10.1208/s12248-020-00450-3

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a Percent change in tumor size represented using RECIST criteria (a “spider” plot); note the diversity of the responses for different virtual patients. b The partial rank correlation coefficient (PRCC) for individual parameters. c (i) Waterfall plots for 1750 simulations while varying (i) TMB, (ii) CEA expression, (iii) CD3 expression on Teff cells, and (iv) CD3 expression on Treg cells

Fig. 7 — a Percent change in tumor size represented using RECIST criteria (a “spider” plot); note the diversity of the responses for different virtual patients. b The partial rank correlation coefficient (PRCC) for individual parameters. c (i) Waterfall plots for 1750 simulations while varying (i) TMB, (ii) CEA expression, (iii) CD3 expression on Teff cells, and (iv) CD3 expression on Treg cells