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. 2020 Jun 12;11:2980. doi: 10.1038/s41467-020-16795-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 10 — Schematic diagram depicting Angpt2 produced from adipocytes could regulate endothelial FA transport via CD36 and FATP3 through integrin α5β1 signaling to accumulate FAs toward SAT. This process prevents ectopic fat accumulation into endocrine organs, and thus prevents insulin resistance.