Table 3.

Subgroup analysis of crude and adjusted hazard ratios (95% confidence interval) of asthma for chronic rhinosinusitis according to age and sex in study I.

Characteristics	HR for CRS
	Crude†	P-value	Adjusted†‡	P-value
Age <20 years old, men (n = 91,914)
Asthma	1.58 (1.48–1.69)	<0.001*	1.50 (1.40–1.60)	<0.001*
Control I	1.00		1.00
Age < 20 years old, women (n = 87,372)
Asthma	1.67 (1.52–1.83)	<0.001*	1.56 (1.41–1.71)	<0.001*
Control I	1.00		1.00
Age 20–39 years old, men (n = 21,644)
Asthma	2.78 (2.28–3.38)	<0.001*	2.41 (1.97–2.96)	<0.001*
Control I	1.00		1.00
Age 20–39 years old, women (n = 44,360)
Asthma	2.17 (1.90–2.47)	<0.001*	1.88 (1.65–2.15)	<0.001*
Control I	1.00		1.00
Age 40–59 years old, men (n = 31,272)
Asthma	2.69 (2.34–3.10)	<0.001*	2.17 (1.87–2.51)	<0.001*
Control I	1.00		1.00
Age 40–59 years old, women (n = 54,508)
Asthma	2.17 (1.97–2.39)	<0.001*	1.85 (1.68–2.05)	<0.001*
Control I	1.00		1.00
Age ≥60 years old, men (n = 30,446)
Asthma	2.13 (1.86–2.45)	<0.001*	1.71 (1.47–1.99)	<0.001*
Control I	1.00		1.00
Age ≥60 years old, women (n = 46,722)
Asthma	2.31 (2.06–2.59)	<0.001*	1.93 (1.71–2.17)	<0.001*
Control I	1.00		1.00

*Cox-proportional hazard regression model, Significance at P < 0.05.

^†Stratified model for age, sex income, and region of residence.

^‡Adjusted model for atopic dermatitis, chronic obstructive pulmonary disease, and Charlson Comorbidity Index.

CRS, chronic rhinosinusitis.