Table 5.

Subgroup analysis of crude and adjusted hazard ratios (95% confidence interval) of chronic rhinosinusitis for asthma according to age and sex in study II.

Characteristics	HRs for Asthma
	Crude†	P-value	Adjusted†‡	P-value
Age <20 years old, men (n = 24,990)
CRS	1.58 (1.48–1.69)	<0.001*	1.51 (1.41–1.61)	<0.001*
Control II	1.00		1.00
Age <20 years old, women (n = 12,570)
CRS	1.67 (1.53–1.83)	<0.001*	1.57 (1.44–1.72)	<0.001*
Control II	1.00		1.00
Age 20–39 years old, men (n = 20,105)
CRS	3.56 (3.14–4.04)	<0.001*	3.04 (2.67–3.47)	<0.001*
Control II	1.00		1.00
Age 20–39 years old, women (n = 21,750)
CRS	2.74 (2.53–3.02)	<0.001*	2.40 (2.18–2.63)	<0.001*
Control II	1.00		1.00
Age 40–59 years old, men (n = 23,465)
Migraine	2.71 (2.46–2.98)	<0.001*	2.14 (1.94–2.37)	<0.001*
Control II	1.00		1.00
Age 40–59 years old, women (n = 26,270)
CRS	2.42 (2.25–2.60)	<0.001*	2.00 (1.86–2.16)	<0.001*
Control II	1.00		1.00
Age ≥60 years old, men (n = 11,535)
CRS	2.18 (1.96–2.42)	<0.001*	1.67 (1.49–1.86)	<0.001*
Control II	1.00		1.00
Age ≥60 years old, women (n = 14,340)
CRS	1.99 (1.82–2.18)	<0.001*	1.64 (1.49–1.80)	<0.001*
Control II	1.00		1.00

*Cox-proportional hazard regression model, Significance at P < 0.05.

^†Stratified model for age, sex income, and region of residence.

^‡Adjusted model for atopic dermatitis, chronic obstructive pulmonary disease, and Charlson Comorbidity Index.

CRS, chronic rhinosinusitis.