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. 2020 Jun 12;10:9537. doi: 10.1038/s41598-020-65692-9

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(A) PCA plot calculated from miRNA read counts in plasma samples from UC patients (RIC and sham groups day 1 before intervention) and HC. (B) PCA plot calculated from miRNA read counts in plasma samples from the RIC group day 11 and the sham group day 11. (C) Volcano plot showing fold change (x-axis) and the statistical significance (y-axis) of each miRNA comparing the UC group (RIC and sham groups day 1 before intervention) and HCs. (D) Volcano plot showing fold change (x-axis) and the statistical significance (y-axis) of each miRNA comparing the RIC group at day 11 and the sham group at day 11 corrected for baseline values of read counts.