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. 2020 Jun 12;10:9587. doi: 10.1038/s41598-020-66509-5

Table 2.

Multivariate regression analysis for risk factors of lymph node metastasis among clinical stage IA (cT1N0M0) peripheral non-small cell lung cancer patients.

Characteristics Odds Ratio 95% Confidence Interval P value
LN metastasis
   Age (young VS elderly) 1.691 0.910–3.142 0.097
   Gender (male VS female) 0.730 0.423–1.259 0.257
   Tumor consistency (pure solid VS part-solid/pure ground glass) 4.505 1.713–11.850 0.002
   Histology (adenocarcinoma VS nonadenocarcinoma) 0.764 0.372–1.564 0.463
   Tumor size (cm) 1.603 1.007–2.551 0.047
   Tumor differentiation (G3 VS G1/G2) 3.860 2.243–6.643 <0.001
   Visceral pleural invasion (yes VS no) 1.529 0.899–2.601 0.117
N1 LN metastasis
   Age (young VS elderly) 2.065 1.049–4.064 0.036
   Gender (male VS female) 0.770 0.435–1.362 0.369
   Tumor consistency (pure solid VS part-solid/pure ground glass) 11.274 2.644–48.069 0.001
   Histology (adenocarcinoma VS nonadenocarcinoma) 0.460 0.226–0.938 0.033
   Tumor size (cm) 1.283 0.790–2.083 0.313
   Tumor differentiation (G3 VS G1/G2) 2.779 1.587–4.867 <0.001
   Visceral pleural invasion (yes VS no) 1.615 0.923–2.825 0.093
N2 LN metastasis
   Age (young VS elderly) 2.400 1.083–5.316 0.031
   Gender (male VS female) 0.612 0.320–1.170 0.137
   Tumor consistency (pure solid VS part-solid/pure ground glass) 3.108 1.033–9.349 0.044
   Histology (adenocarcinoma VS nonadenocarcinoma) 1.422 0.555–3.640 0.463
   Tumor size (cm) 1.516 0.867–2.652 0.145
   Tumor differentiation (G3 VS G1/G2) 6.250 3.172–12.314 <0.001
   Visceral pleural invasion (yes VS no) 1.738 0.935–3.232 0.080

Note: LN = lymph node.